He's the producer of "Hamilton," the runaway smash hit musical about the founding of America that is expected to generate over a billion dollars in revenue.
In addition to "Hamilton," Seller is the producer of "Avenue Q," "In The Heights" and "Rent." All four shows have won Tony Awards for best musicals.
Despite his intimidating track record of success, he is not infallible.
In a podcast with Kara Swisher, executive editor of tech site Recode, Seller said that for each of his big successes he's had equally bad failures.
"I fail all the time," said Seller. "And I have to be willing to fail in order to succeed."
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As the producer of "Hamilton," Seller is responsible for the business end of the equation. He needs to organize sales, marketing, salaries, etc. Every show he runs is like a start-up: He has investors that he needs to pay back.
So what's gone wrong when Seller failed? What mistakes did he make as an entrepreneur?
"I didn't follow my heart," Seller said of his mistakes.
He cited the musical "High Fidelity," which ran on Broadway for only a few days. "My heart said, 'This isn't working,' but my head said, 'Keep going.'" He said he didn't like the movie the play was based on, but he believed in the artists so much he charged ahead anyway.
The lesson: "Every time I don't follow my heart, that's when I am bound to get in trouble."
Disclaimer: - Following article come from CNBC